The massive strike – the first direct US action against President Bashar al-Assad’s government and Trump’s biggest military decision since taking office – marked a dramatic escalation in American involvement in Syria’s six-year civil war.
It followed days of outrage at images of dead children and victims suffering convulsions from the suspected sarin gas attack in the rebel-held town of Khan Sheikhun.
US officials said 59 Tomahawk cruise missiles were fired from Navy ships in the Mediterranean at the Shayrat airfield at 3:40 a.m. (0040 GMT), targeting the base from where Washington believes Tuesday’s deadly attack was launched.
Calling the strike a “flagrant aggression,” the Syrian army said it had killed six people and caused extensive damage to the base.
The attack was hailed by the Syrian opposition and supported by US allies including Britain, France, Israel, Saudi Arabia and Turkey.
But it was denounced by Assad allies Iran and Russia, with Moscow warning that it would inflict “considerable damage” on US-Russia ties and halting an agreement with Washington aimed at avoiding clashes in Syrian airspace.
Trump announced the strike in a brief televised address delivered hours after the UN Security Council failed to agree on a probe into the suspected chemical attack.
Syria’s military has denied ever using chemical weapons, but Trump accused Assad of a “very barbaric attack” in which “even beautiful babies were cruelly murdered.”
At least 86 people, including 27 children, were killed in Khan Sheikhun and more than 500 wounded.
“Tonight I call on all civilized nations to join us in seeking to end this slaughter and bloodshed in Syria and also to end terrorism of all kinds and all types,” Trump said.
The missiles were fired from the USS Porter and the USS Ross, which belong to the US Navy’s Sixth Fleet and are in the eastern Mediterranean.
The strike targeted radars, aircraft, air defense systems and other logistical components at the base south of Homs in central Syria.
US officials said measures had been put in place to avoid hitting sarin gas they said was stored at the airfield.
“The airbase was almost completely destroyed – the runway, the fuel tanks and the air defenses were all blown to pieces,” the Syrian Observatory for Human Rights said.
The Britain-based monitoring group said at least seven servicemen were killed, including an air commodore.
The base was the second most important for Syria’s air force, Observatory chief Rami Abdel Rahman told AFP, after the Latakia airbase in Assad’s coastal heartland where Russia also maintains extensive facilities.
In a statement read on state television, the Syrian army confirmed the strike and gave the toll of six dead, without specifying whether they were civilians or military personnel.
It accused Washington of being allied with jihadists like the Islamic State group, and said it was seeking to “justify this aggression” by pointing the finger at Damascus for the suspected chemical attack “without knowing the truth.”